Naindeep Kaur
Department of Biotechnology, Panjab University, India
Title: Association of ANRIL rs1333049 polymorphism with coronary artery disease in North Indian population
Biography
Biography: Naindeep Kaur
Abstract
Aim: The present study attempts to delineate the allelic and genotypic frequencies of rs1333049 and the risk of CAD in North Indian population.
Methods: A case-control association study was performed on 1000 individuals (500 angiographically confirmed CAD patients and 500 healthy control subjects) from North India and genotyped using ARMS-PCR.
Results: Multiple logistic regression revealed a significant association between rs1333049 polymorphism and CAD after adjustment for confounders [p=0.002, OR=2.883, 95% CI (1.475–5.638) and p=0.000, OR=6.717, 95% CI (3.444-13.102) for heterozygous and mutant genotype respectively]. Stratified analysis showed that the mutant genotype was associated with a greater risk of CAD in subjects above 40 years of age (adjusted OR =2.483, 95% CI: 1.635– 3.770) and in females subjects (adjusted OR =9.248, 95% CI: 2.666– 32.077).
Conclusion: Ours is the first study revealing the genotypic and allelic frequencies of rs1333049 in North Indian population and provides an unprecedented evidence for the association of rs1333049 variant with CAD risk. Also gender and age related associations are observed thereby
confirming the use of this SNP as a genetic marker for screening of CAD in North Indian population.