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23rd European Heart Disease and Heart Failure Congress

Paris, France

Karan Singh Peepre

Gandhi Medical College, India

Title: Role of 99mtc-mibi myocardial perfusion imaging in the diagnosis of coronary artery disease


Biography: Karan Singh Peepre


Myocardial perfusion  imaging  uses an intravenously administered  radiopharmaceutical   99mTc-MIBI  to depict the distribution  of  blood flow in the myocardium. Perfusion imaging  identifies areas of relatively reduced  myocardial blood flow associated with ischemia or scar. The relative regional distribution of perfusion can be assessed at rest, during cardiovascular stress, or both. Coronary artery disease is the  leading cause of death worldwide, and very costly in management. Currently, use of  Dual head gamma camera SPECT-CT  modality in cardiac patient’s  is very good,accuarte and  justified   and   provides added  values  with  respect to prognostic, risk stratification, and cost parameters. CT is used for calcium scoring. The three-dimensional images produced by this study are called perfusion images  because  they show which areas of  the heart muscle are perfused, or supplied, with blood.  99mTc-Sestamibi  SPECT acquisition is initiated 30 minutes after isotope injection. During image interpretation, a semiquantitative visual interpretation  is performed    in the apical, midventricular, and basal slices of the short-axis views and   apical segments on the midventricular long-axis slice. Each segment  has  scored using a 5-point scoring  system (0 indicated normal; 1, equivocal; 2, moderate; 3, severe reduction of radioisotope uptake; and 4, absence of detectable tracer uptake in a segment). Stress/Rest MPI is the most accurate test available for diagnosing coronary artery disease (CAD) early in patients who may be at risk for a heart attack. Abnormal perfusion scans are highly indicative of CAD. MPI  show  overall  function of  the heart  walls and  assess damaged   heart muscle following a heart attack