Karan Singh Peepre
Gandhi Medical College, India
Title: Role of 99mtc-mibi myocardial perfusion imaging in the diagnosis of coronary artery disease
Biography
Biography: Karan Singh Peepre
Abstract
Myocardial perfusion imaging uses an intravenously administered radiopharmaceutical 99mTc-MIBI to depict the distribution of blood flow in the myocardium. Perfusion imaging identifies areas of relatively reduced myocardial blood flow associated with ischemia or scar. The relative regional distribution of perfusion can be assessed at rest, during cardiovascular stress, or both. Coronary artery disease is the leading cause of death worldwide, and very costly in management. Currently, use of Dual head gamma camera SPECT-CT modality in cardiac patient’s is very good,accuarte and justified and provides added values with respect to prognostic, risk stratification, and cost parameters. CT is used for calcium scoring. The three-dimensional images produced by this study are called perfusion images because they show which areas of the heart muscle are perfused, or supplied, with blood. 99mTc-Sestamibi SPECT acquisition is initiated 30 minutes after isotope injection. During image interpretation, a semiquantitative visual interpretation is performed in the apical, midventricular, and basal slices of the short-axis views and apical segments on the midventricular long-axis slice. Each segment has scored using a 5-point scoring system (0 indicated normal; 1, equivocal; 2, moderate; 3, severe reduction of radioisotope uptake; and 4, absence of detectable tracer uptake in a segment). Stress/Rest MPI is the most accurate test available for diagnosing coronary artery disease (CAD) early in patients who may be at risk for a heart attack. Abnormal perfusion scans are highly indicative of CAD. MPI show overall function of the heart walls and assess damaged heart muscle following a heart attack