Heart Diseases

Biography

Biography: Mahmood Hasan Khan

Abstract

Coronary heart disease is the most common category of the heart disease. cTnI is 100% tissue-specific for the myocardium and a very sensitive and specific marker for acute myocardial infarction. Ventricular function provides information on systolic function as well as diagnosis and prognosis. The study aimed at investigating the impact of LVEF on elevated Troponin-I level in patients with first attack of NSTEMI. This cross-sectional analytical study was conducted in the department of cardiology in Mymensingh Medical College Hospital from December, 2015 to November, 2016. Total 130 first attack of NSTEMI patients were included considering inclusion and exclusion criteria. The sample population was divided into two groups: Group–I: Patients with first attack of NSTEMI with good LV function (LVEF: ≥55%). Group–II: Patients with first attack of NSTEMI with LV systolic dysfunction (LVEF: <55%). In this study mean Troponin-I of were 5.53±7.43 and 16.46±15.79 ng/ml respectively. It was also statistically significant (p<0.05). The mean LV ejection fraction value were 65.31±10.30% and 40.17±4.62% respectively. It was statistically significant (p < 0.05). The Echocardiography showed that patients with high Troponin-I level had low LVEF and patients with low Troponin-I level had preserved LVEF. Analysis showed that patients with highest level of Troponin-I had severe left ventricular systolic dysfunction (LVEF <35%) and the patients with the lowest levels of Troponin-I had preserved systolic function (LVEF ≥ 55%). In our study, it also showed that the levels of Troponin-I had negative correlation with LV ejection fraction levels with medium strength of association (r= -0.5394, p=0.001). Our study also discovered that Troponin-I level ≥6.6 ng/ml is a very sensitive and specific marker for LV systolic dysfunction.