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Jeffri Gunawan

Dr. Cipto Mangunkusumo Hospital, Indonesia

Title: Redefining optimal serum potassium target in acute coronary syndrome: first study report from Indonesia

Biography

Biography: Jeffri Gunawan

Abstract

Background: Acute coronary syndrome (ACS) is the leading cause of increased morbidity and mortality across the globe. This mortality was known to be associated to the serum potassium level on admission. Conflicting results exist between recent studies and established guidelines, while in Indonesia it becomes more complex due to the limitation of provision of drugs by the National Healthcare Insurance/Jaminan Kesehatan Nasional (JKN).

Aims:         To determine the association between serum potassium levels on admission of subjects with acute coronary syndrome and in-hospital mortality. Especially in the era of JKN. To redefine the optimal serum potassium target in acute coronary syndrome patients.

Methods: Methods. Included in the study were 673 acute coronary syndrome patients hospitalised in Indonesian National Cipto  Mangunkusumo Hospital. The outcome of the study was all-cause   in-hospital   mortality. Logistic regression models adjusted for risk factors, hospital treatment and co-morbidities were constructed.

Results: Total of 163 patients (24.22%)          with abnormal serum potassium (K  <  3.50  mEq/L  or           >  5.0  mEq/L)  and  510  subjects  with  normal  serum  potassium (75.78%). Logistic  regression  shows  significant  association  between  serum  potassium level  on admission  and  in-hospital  mortality  with  p  value  of  0.04  (adjusted  RR  2.184; 95% CI: 1.037-4.601).  The  risk  of  dying  for  patients  with serum  potassium  of  4.0-<4.5 mEq/L was increased compared to subjects with potassium of 3.50-<4.0 mEq/L (relative risk 1.4; 95% CI: 0.497-3.93).

Conclusion: ACS patients with abnormal serum potassium level at admission have significant association with in-hospital mortality. Admission serum potassium level of > 4.0 mEq/L may be associated with increased mortality risk in patients with ACS. Optimal target of serum potassium level in acute coronary syndrome may be considered to be redefined to a range of 3.50-3.99 mEq/L.