Syeda Humayra
Cyberjaya University College of Medical Science, Malaysia
Title: The Presumptive Role of Takotsubo Syndrome as Collateral Damage Inflicted by Mass Population Stress Events
Biography
Biography: Syeda Humayra
Abstract
Takotsubo syndrome- The acquired cardiomyopathy that has recently gained popularity as ‘broken heart syndrome’ can be described as an acute left ventricular dysfunction presented mostly in postmenopausal women followed by intense stressful event, but its exact pathophysiology remains unclear. The term first came into existence in early 1990’s in Japan as reported by Hikaru Sato et. al. Initially originated from Japanese ‘octopus trap’ because of its distinctive resemblance in shape with the left ventricle in systole. TTC being an unconventionally rare, under recognized syndrome has emerged out as a momentous form of acute cardiac failure over the last decade. Several researches have been revolving around it to quantify its extensive damage on the heart. Clinical diagnosis of takotsubo is largely misguiding due to its inevitable similarity with ACS, but in the absence of evident coronary obstruction in angiographic presentation. Although, there is substantial elevation of cardiac biomarkers like troponin and natriuretric peptide (pro-BNP and NT- pro-BNP) which are major diagnostic keys in differentiating TS from MI.
Methodology: The aim of this retrospective observational study is to investigate and establish the epidemiological events of takotsubo during mass population stress (taking into account the tragic cases of Malaysia Airlines Flight 370 and MH17; and the recent fall of UMNO in 2018 election period ); to contribute sufficient statistical data on the International Takotsubo Registry to fill in the gaps lacking geographic variation and demographic profile due to limited literature on TTC from Asian countries.
Suggestive Findings: It’s rationally conceptualized that TS cases reported under stressful scenario would be higher in comparison to control, which would help determine cardiovascular complications, misdiagnosed cases, recurrent TTC and mortality rates.
Conclusion: Recent studies suggest that TTC isn’t rare anymore, but awareness is required to facilitate better management mostly in emergency department. As it presents with catecholamine toxicity and enhanced nitric oxide signalling; providing incorrect treatment would eventually harm the patient. Therefore, acknowledging the overall effect it has on patient’s heart is certainly important.