University of Southampton
My research interests are the role of DNA damage and repair mechanisms in the pathogenesis of atherosclerosis as well as the potential for utilizing circulating micro-RNAs in elucidating the pathophysiology of isolated coronary calcification. I am currently the principle investigator of a study examining the expression of genes involved in the DNA damage and repair-signaling pathways in peripheral blood mononuclear cells in patients with coronary artery disease and determining whether the expression of such genes can be correlated with plaque anatomy. I am also the principle investigator of a study investigating the potential for a “micro-RNA-signature” in patients with isolated coronary artery calcification as measured by CT coronary angiography. microRNAs are isolated from PBMCs for microarray analysis to predict potential micro-RNA targets and to examine the molecular/signalling pathways that characterise the pathophysiology of isolated coronary artery calcification in humans.
Coronary Artery Disease, Interventional Cardiology