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Michael Mahmoudi

Michael Mahmoudi

Associate Professor
University of Southampton


My research interests are the role of DNA damage and repair mechanisms in the pathogenesis of atherosclerosis as well as the potential for utilizing circulating micro-RNAs in elucidating the pathophysiology of isolated coronary calcification. I am currently the principle investigator of a study examining the expression of genes involved in the DNA damage and repair-signaling pathways in peripheral blood mononuclear cells in patients with coronary artery disease and determining whether the expression of such genes can be correlated with plaque anatomy. I am also the principle investigator of a study investigating the potential for a “micro-RNA-signature” in patients with isolated coronary artery calcification as measured by CT coronary angiography. microRNAs are isolated from PBMCs for microarray analysis to predict potential micro-RNA targets and to examine the molecular/signalling pathways that characterise the pathophysiology of isolated coronary artery calcification in humans.

Research Interest

Coronary Artery Disease, Interventional Cardiology