According to World Health Organisation (WHO), the mortality from coronary heart disease in Indonesia reached 138,380 or 10% of total deaths per year in 2014. Dyslipidemias are disorders of lipoproteins, that can be manifested by the elevation of serum total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride concentrations, and a decrease in the high-density lipoprotein (HDL) cholesterol concentration. Hydropinic therapy (drinking of mineral water), in particular water that is rich in natural bicarbonate, has shown to have an effect in reducing cholesterolaemic and lipaemic levels by increasing the lipoprotein metabolism. This study compares the consumption of a mineral water that is rich in natural bicarboante (ARDESY, France) (MWH), versus a marketed mineral water that is low in bicarbonate (MWL), and their effects in lipoprotein metablosim in high cholesterol males subjects. Twenty-two males with elevated serum total cholesterol, and a mean BMI of between 23.9(±4.4) kg/m2 were randomised into 2 groups. Each group received either (MWH) (n=14) (sponsored by ARDESY, France), or MWL (n=8). Subjects drank 1.25 liter of designated water per day for 28 weeks. Three visits were planned at the clinical center post screening, which included first day before mineral water was consumed (V1), 15th day (V2), and 29th day (V3). Results indicated that there was significant reduction in serum total cholesterol (p=0.002) and LDL cholesterol (p<0.001) in subjects drinking MWH, but not in the MWL group. There was no significant change in BMI, blood pressure, and urine pH. In conclusion, regular consumption of rich bicarbonated water can significantly lower total cholesterol and LDL-c in moderate risk cholesterol males. Validation in a randomized control trials is currently underway.