Mohadese Firouzi has finished his cardiology in Zanjan university of medical science in 2017
Background: T helper mediated responses to CADs can affect the disease progression. IL-27 plays a role as a double-edged sword in T helpers regulating and Has important roles in CAD progression.The aim of this study is to determine the relations of plasma IL-27 level and CAD patients' characteristics. Materials: 121 patients with CAD were enrolled in this study. Needed information gathered by questionnaire. Blood samples of each group were obtained at the time of admission to the emergency room and 3 months after revascularization. Left Ventricle Ejection Fraction (LVEF) and Gensini Score were recorded after revascularization. IL-27 plasma level was measured by ELISA. Results: The mean of pre-procedure IL-27 level in each group of patients were 255.86±116.23 pg/ml in AMI patients, 145.08±114.52 pg/ml in UA patients, 92.53±40.22 pg/ml in SA patients and 136.67±78.02 pg/ml in control group, the defference between AMI and other groups was significant (p<0.05). The mean of post-procedure IL-27 level in each group of patients was 174.36±123.15 pg/ml in AMI patients, 172.49±115.06 pg/ml in UA patients, 202.61±122.22 pg/ml in SA patients and 132.62±141.59 pg/ml in control group there was no significant difference between each pair of groups (p=0.144). Alteration of IL-27 plasma level 3 months after revascularization compared with pre-revascularization level was significant in all groups except control group, this change was an increment in UA and SA patients and decrement in AMI group (p<0.05). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups except in SA (p<0.005 for both Gensini score and LVEF). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups (p≥0.05). Conclusion: Plasma level of IL-27 is acutely relative with the extent of the coronary atherosclerotic plaque rupture area. And it can be used as a novel biomarker for surveying the stability and coronary plaque rupture status and can help cardiologists to modulate the medications and decide for next therapeutic steps
Mariya Maslarska is a medical student in her final year at the Albert-Ludwig University of Freiburg,Germany. Together with Christoph Weis she is a member of the Shear wave elastography research group under the supervision of Prof. Christoph Hehrlein and his team at the Vascular Center of the University Medical Center of Freiburg. They have been intensively researching the diagnostic impact of shear wave elastography for patients with chronic heart failure
It is well established that patients with heart failure often suffer from severe peripheral muscular weaknesses resulting in difficulties performing daily life tasks. Reduced oxygen delivery, lowered lactate turnover and mitochondrial capacity are thought be responsible for a diminished contractility of peripheral muscles in heart failure patients. Purpose: We sought to investigate whether shear wave elastography (SWE) is useful tool in identifying weaknesses in extension (stretch) and flexion of peripheral muscles. Material and Methods: 28 patients (pts) with chronic congestive heart failure (CHF, age 64,9 ± 13) with mid-range (HFmrEF,LVEF 40-49%)and reduced ejection fraction (HFrEF,LVEF<40%) and 17 healthy control persons(CP, age 55,8±20,4, p= 0,115) participated in the study. SWE of the gastrocnemius- and flexor carpi muscles was performed using a Loqiq E9 XDClear ultrasound maschine applying a 9L-linear array scanner. Resting kPa and exercise kPa between the muscles were assessed within a range of 0-300 kPa. Data were expressed as mean±SD and compared using the unpaired Student’s t-test with Bonferonis correction whenever appropriate. Results: Resting kPa was not different in CHF and CP , neither for muscle flexion (19.,8 ±5,1 vs. 20,5 ± 6 p=0,683) nor in the muscle extension group (12,7 ± 3,9 vs 13,3 ± 3; p=0,602). Exercise -kPA of gastrocnemius muscle (57,2.±19,5 vs. 87,1± 13,7; p<0,001) and flexor carpi muscle(44,3± 13,3 vs. 61,6± 21.7; p=0,005) were markedly reduced in CHF- compared with CP pts. Conclusion: Shear wave elastography appears to be an extremely valuable tool to diagnose muscle weaknesses in patients with chronic heart failure.