23^rd European Heart Disease and Heart Failure Congress February 19-21, 2018 Paris, France

Biography:

Prof. Dr.Karan Peepre, has completed  his MBBS,MD,DNM at the age of 32  years from The University of  jabalpur, University of Mumbai and Devi Ahilya University,Indore,India.  He has been  trained in Spect-CT,PET-CT, Nuclear Medicine,Nuclear Cardiology from AIIMS,New Delhi, World number One Emory University, School of Medicine, Atlanta,USA and Nuclear Medicine Centre,BARC,TMC,Mumbai. At present he is  Professor and Head  of Department of  Nuclear medicine and Superintendent of Sultania lady Hospital,Gandhi Medical College,Bhopal,India.he has presented many research  papers & delivered lectures  in national and international conferences and chaired sceintific sessions, He has published more than 15  papers in reputed journals.3-Gold medals are in his credit

Abstract:

Myocardial perfusion  imaging  uses an intravenously administered  radiopharmaceutical   99mTc-MIBI  to depict the distribution  of  blood flow in the myocardium. Perfusion imaging  identifies areas of relatively reduced  myocardial blood flow associated with ischemia or scar. The relative regional distribution of perfusion can be assessed at rest, during cardiovascular stress, or both. Coronary artery disease is the  leading cause of death worldwide, and very costly in management. Currently, use of  Dual head gamma camera SPECT-CT  modality in cardiac patient’s  is very good,accuarte and  justified   and   provides added  values  with  respect to prognostic, risk stratification, and cost parameters. CT is used for calcium scoring. The three-dimensional images produced by this study are called perfusion images  because  they show which areas of  the heart muscle are perfused, or supplied, with blood.  99mTc-Sestamibi  SPECT acquisition is initiated 30 minutes after isotope injection. During image interpretation, a semiquantitative visual interpretation  is performed    in the apical, midventricular, and basal slices of the short-axis views and   apical segments on the midventricular long-axis slice. Each segment  has  scored using a 5-point scoring  system (0 indicated normal; 1, equivocal; 2, moderate; 3, severe reduction of radioisotope uptake; and 4, absence of detectable tracer uptake in a segment). Stress/Rest MPI is the most accurate test available for diagnosing coronary artery disease (CAD) early in patients who may be at risk for a heart attack. Abnormal perfusion scans are highly indicative of CAD. MPI  show  overall  function of  the heart  walls and  assess damaged   heart muscle following a heart attack

Biography:

Samér Kassem is a cardiac surgeon who works at Centro Cardiologico Monzino, in Milan.
He was born in Siria, where he had spent the first years of his life, between the cities of Latakia and Damascus. His working experience began with General Surgery. During that period he performed a lot of procedures, showing great competence. He then attended the Cardiac Surgery Program and took part to both adult and pediatric surgery. Once he migrated to Italy, he associated with the best trained surgeons at the most specialized centres of the North of the Country. In this way, he improved and refined his skills in both surgical practice and scientific research. Since 2004 he stably operates at Centro Cardiologico Monzino, where he found the excellence in Cardiac Surgery and, most of all, the opportunity to develop new personal surgical techniques in different fields. In fact, doctor Kassem has large and deep experience and knowledge and also a vivid interest in mitral and aortic valve surgery, aortic arch surgery, surgery of the ascending aorta and surgery of left ventricular aneurysms and, finally, coronary surgery. He has recently approached hypertrophic cardiomiopathy and its surgical management.
Kassem is also a talented oil painter. After studying art in Damascus, he has had the possibility to blend two different cultures, the Syrian and Italian one, once he moved to Italy. He had recently performed his last exhibition in an historical place along the Adda river, near Milan, where the “genius” Leonardo DaVinci left important traces of his amazing and all-life-long lasting work

Abstract:

Introduction: According to current guidelines, in patients with valvular heart disease (VHD), cardiac surgery should be considered before severe ventricular dysfunction develops.

Methods: A 67-years old man was referred to us with moderate mitral regurgitation (MR). He was previously diagnosed at Our Centre for arrhythmogenic RV dysplasia (ARVD), managed with transcatheter ablation (TCA) for paroxistical atrial fibrillation (PAF) and an Implantable Cardioverter Defibrillator (ICD) to prevent further malignant arrhythmias.

Results: The preoperative transthoracic echocardiogram (TTE) showed bad RV and preserved LV function. Although the MV wasn’t on time for surgery, we decided to treat the patient to prevent biventricular dysfunction.

The patient successfully underwent mitral valve replacement (MVR), without any attempt to repair the valve, to reduce the time on cardiopulmonary bypass (CPB) and left atrial appendage (LAA) closure.

The postoperative (PO) course was uneventful and the patient was discharged on the PO day 7th.

Discussion: The indication for MV surgery changes in presence of ARVD or RV failure due to other conditions. In normal population, surgery is performed in case of severe MR, as suggested by current guidelines, while in these patients, when the MR is still moderate, we can’t no longer ‘wait and see’. According to our experience, this can be considered the right time to indicate surgery

Biography:

Ramzi EL FEGHALI has completed his PhD at the age of 27 years from Lyon 1 University and attached lecturer, postdoctoral, and young research engineer studies from the University of Versailles, the French National Center of Scientific Research and the French National Institute of Medical Research respectively. Currently he is the Director of Omics & Nanotech and a lecturer of science at private schools. He has published over 10 papers and was a member of the International Society of Computational Biology and the International Society of Clinical Biostatistics and a peer reviewer for Dove Medical Press

Abstract:

 

Metabolic alterations and hypertension are the major risk factors of heart diseases development. Today a panel of 40 biomarkers jointly with clinical markers are used by the cardiologists for the diagnosis of coronary and heart diseases. Some predictive biomarkers are used for the prognostic of the coronary and heart diseases but those biomarkers present a lack of accuracy due to the complex molecular system of the blood, the vessels and the heart. For this reason, I have proposed a new study design coupled to a robust biostatistics analysis in order to select the most relevant predictive protein biomarkers of atherosclerosis and hypertension. Material and methods: The plasma of 30 patients with 6 different phenotypes (hypertension, hypercholesterolemia, diabetes mellitus, stroke/transient ischemic attack, coronary artery diseases  and healthy controls) included by the Utrecht Medical Centre University in Netherlands was profiled with the LC-MS/MS proteomics mass spectrometry technique after the depletion of the major proteins and the digestion of the proteome. A coupled robust comparative statistical analysis allowed to sort the identified proteins and to validate the most discriminative and predictive set of proteins that are under patenting. Conclusion: Twenty robust predictive biomarkers including renin, phospholipases, membrane matrix proteins and an uncharacterized protein were selected after this pilot study as a predictive set of biomarkers for the prognosis of atherosclerosis and hypertension. Acknowledgements: This work has been partly funded with a grant from the French Research Institute for Development of Marseille; the first experiments were realized by the CLinical Innovation Proteomic Platform of Dijon in France

Biography:

DR. ESSAM HAMED AMIN ALI; DBA, MQM, TQM is Professional with strong quality management and Hospital Management, planning and interpersonal skills possessing 26 years of rich experience in the health industry, Experience in JCI with an established hospital."

Abstract:

Total Quality Management (TQM) is not a new concept.

In 1931; W.A Shewhart recognized that variability within Industry production could be understood using the principles of probability and statistics (Schultz, 1988).

Variability is the dispersion exhibited by evaluations of successive events resulting from a common process.

During the 1950’s, Joseph J.Juran tackled the cost of achieving quality and discovered it could be divided into avoidable and avoidable cost (Crosby ,1987).W. Edward Deming, in the 1950’s, asked “Who can put a price on a satisfied costumer, and who can figure the cost of dissatisfied one?”(Strickland, 1989).

TQM is just a program but an active corporate strategy to optimize resources and reduce inefficiencies, rework cost and costumer complaints.

TQM seeks to raise the collective vision of quality and change the focus from the product to all the contributing processes that determine the quality of the product (Strickland, 1989).

TQM applies to all facets of clinical and administrative operations .Its implementation within health care is unique; therefore, to fully understand this environment, three fundamental assumptions must be made.

The first is that medicine is a service field, not just technical or industrial.

Second, is the linear process of medicine, all parts must come together at the right time and place for the process to progress.

Third, the limiting steps in each process are either process or resource – driven (Wright-Patterson AFB Study, 1989).

TQM in health care strives to refine systems to meet or exceed goals for achieving quality technical outcomes, maintaining cost effectiveness, and for ensuring the most effective use of resources for providing continuous quality service to all customers

Biography:

Adiba Tarannum has completed her MBBS from Dhaka University and now pursuing her career in clinical nutrition. She also has a great interest in the public health context of clinical nutrition.  She has attended few conferences regarding this. She is trying to establish a field of clinical nutrition in Bangladesh which is becoming major issues in developing countries. She is doing several researches regarding nutritional issues of cardiovascular disease and obesity

Abstract:

Cardiovascular diseases are the most common causes of premature morbidity and mortality worldwide. Cardiovascular disease burden is increasing in developing country like Bangladesh which is creating adverse effect to whole health system. A cross-sectional, descriptive study among the higher secondary students of Bangladesh was performed using convenience sampling to assess the student’s knowledge and perception of cardiovascular risk factors and prevention. Students had a good knowledgeable about cardiovascular risk factors but did not perceive themselves at risk for cardiovascular disease. More than 60% students have one or more risk behavior related to cardiovascular diseases. The knowledge about cardiovascular diseases risk factors and prevention among the participants is high, but it has little role on practicing health life

Biography:

Fereidoon Noohi Bezanjani has completed his Internship from Mashhad University and internal medicine specialty from Shaheed Beheshty University of Medical Sciences. He has completed cardiology from Shaheed Rajai Cardiovascular Medical Center, Iran University of Medical Sciences, Tehran, Iran. He also has 103 published articles

Abstract:

Introduction: Thrombotic and thromboembolic events are important causes of mortality and morbidity in patients with prosthetic heart valve. Prosthetic heart valve thrombosis (PVT) incidence is ranging from 0•1% to almost 6% per patient-year in mitral and aortic valves, and up to 20% in tricuspid valve. The aim of this study is to evaluate the factors that may contribute to PVT. Method: This is a descriptive study of all Rajai Heart Centre’s patients with prosthetic heart valve malfunction, within a year. According to the echocardiographic (trans-thoracic and trans-esophageal) and fluoroscopic findings, the patients were divided into 2 groups. The first group included patients with thrombosis and the second group included patients without thrombosis. The patients’ demographic, clinical and laboratory data recorded in the desired form and then compared with each group. Result: A hundred and forty two patients included in this study. Ninety six patients (66.2%) were female and 48(33•8%) were men with the mean age of 49•8 and the standard deviation of 13•13. Ninety four (66•2%) of patients diagnosed with thrombosis and 48 (33•8%) patients were without thrombosis. There was no significant correlation between thrombosis and sex, age, season of hospitalization, ESR, blood group and patient’s ejection fraction. There was significant correlation between thrombosis and unstable INR, recent infection history, atrial fibrillation, multi-valve replacement, concurrent use of the warfarin and aspirin and the presence of proteinuria. Conclusion: Totally, we can say unstable INR was the most important risk factor for PVT and the incidence of thrombosis was lower in patients with regular INR control. Thus, informing and teaching the patients can play a key role in decreasing the incidence of PVT. In addition, according to the higher rates of thrombosis in patients with the history of recent infection especially upper respiratory infection, this factor can be a candidate in prosthetic valve risk assessment and needs further investigations with larger populations

Biography:

Mohadese Firouzi has finished his cardiology in Zanjan university of medical science in 2017

Abstract:

Background: T helper mediated responses to CADs can affect the disease progression. IL-27 plays a role as a double-edged sword in T helpers regulating and Has important roles in CAD progression.The aim of this study is to determine the relations of plasma IL-27 level and CAD patients' characteristics. Materials: 121 patients with CAD were enrolled in this study. Needed information gathered by questionnaire. Blood samples of each group were obtained at the time of admission to the emergency room and 3 months after revascularization. Left Ventricle Ejection Fraction (LVEF) and Gensini Score were recorded after revascularization. IL-27 plasma level was measured by ELISA. Results: The mean of pre-procedure IL-27 level in each group of patients were 255.86±116.23 pg/ml in AMI patients, 145.08±114.52 pg/ml in UA patients, 92.53±40.22 pg/ml in SA patients and 136.67±78.02 pg/ml in control group, the defference between AMI and other groups was significant (p<0.05). The mean of post-procedure IL-27 level in each group of patients was 174.36±123.15 pg/ml in AMI patients, 172.49±115.06 pg/ml in UA patients, 202.61±122.22 pg/ml in SA patients and 132.62±141.59 pg/ml in control group there was no significant difference between each pair of groups (p=0.144). Alteration of IL-27 plasma level 3 months after revascularization compared with pre-revascularization level was significant in all groups except control group, this change was an increment in UA and SA patients and decrement in AMI group (p<0.05). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups except in SA (p<0.005 for both Gensini score and LVEF). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups (p≥0.05). Conclusion: Plasma level of IL-27 is acutely relative with the extent of the coronary atherosclerotic plaque rupture area. And it can be used as a novel biomarker for surveying the stability and coronary plaque rupture status and can help cardiologists to modulate the medications and decide for next therapeutic steps

Biography:

Mohadese Firouzi has finished his cardiology in Zanjan university of medical science in 2017

Abstract:

Background: T helper mediated responses to CADs can affect the disease progression. IL-27 plays a role as a double-edged sword in T helpers regulating and Has important roles in CAD progression.The aim of this study is to determine the relations of plasma IL-27 level and CAD patients' characteristics. Materials: 121 patients with CAD were enrolled in this study. Needed information gathered by questionnaire. Blood samples of each group were obtained at the time of admission to the emergency room and 3 months after revascularization. Left Ventricle Ejection Fraction (LVEF) and Gensini Score were recorded after revascularization. IL-27 plasma level was measured by ELISA. Results: The mean of pre-procedure IL-27 level in each group of patients were 255.86±116.23 pg/ml in AMI patients, 145.08±114.52 pg/ml in UA patients, 92.53±40.22 pg/ml in SA patients and 136.67±78.02 pg/ml in control group, the defference between AMI and other groups was significant (p<0.05). The mean of post-procedure IL-27 level in each group of patients was 174.36±123.15 pg/ml in AMI patients, 172.49±115.06 pg/ml in UA patients, 202.61±122.22 pg/ml in SA patients and 132.62±141.59 pg/ml in control group there was no significant difference between each pair of groups (p=0.144). Alteration of IL-27 plasma level 3 months after revascularization compared with pre-revascularization level was significant in all groups except control group, this change was an increment in UA and SA patients and decrement in AMI group (p<0.05). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups except in SA (p<0.005 for both Gensini score and LVEF). The relation between Gensini score and EF with pre-revascularization IL-27 plasma level was not significant in none of all groups (p≥0.05). Conclusion: Plasma level of IL-27 is acutely relative with the extent of the coronary atherosclerotic plaque rupture area. And it can be used as a novel biomarker for surveying the stability and coronary plaque rupture status and can help cardiologists to modulate the medications and decide for next therapeutic steps

Biography:

Mariya Maslarska is a medical student in her final year at the Albert-Ludwig University of Freiburg,Germany. Together with Christoph Weis she is a member of the Shear wave elastography research group under the supervision of Prof. Christoph Hehrlein and his team at the Vascular Center of the University Medical Center of Freiburg. They have been intensively researching the diagnostic impact of shear wave elastography for patients with chronic heart failure

Abstract:

It is well established that patients with heart failure often suffer from severe peripheral muscular weaknesses resulting in difficulties performing daily life tasks. Reduced oxygen delivery, lowered lactate turnover and mitochondrial capacity are thought be responsible for a diminished contractility of peripheral muscles in heart failure patients. Purpose: We sought to investigate whether shear wave elastography (SWE) is useful tool in identifying weaknesses in extension (stretch) and flexion of peripheral muscles. Material and Methods: 28 patients (pts) with chronic congestive heart failure (CHF, age 64,9 ± 13) with mid-range (HFmrEF,LVEF 40-49%)and reduced ejection fraction (HFrEF,LVEF<40%) and 17 healthy control persons(CP, age 55,8±20,4, p= 0,115) participated in the study. SWE of the gastrocnemius- and flexor carpi muscles was performed using a Loqiq E9 XDClear ultrasound maschine applying a 9L-linear array scanner. Resting kPa and exercise kPa between the muscles were assessed within a range of 0-300 kPa. Data were expressed as mean±SD and compared using the unpaired Student’s t-test with Bonferonis correction whenever appropriate. Results: Resting kPa was not different in CHF and CP , neither for muscle flexion (19.,8 ±5,1 vs. 20,5 ± 6 p=0,683) nor in the muscle extension group (12,7 ± 3,9 vs 13,3 ± 3; p=0,602). Exercise -kPA of gastrocnemius muscle (57,2.±19,5 vs. 87,1± 13,7; p<0,001) and flexor carpi muscle(44,3± 13,3 vs. 61,6± 21.7; p=0,005) were markedly reduced in CHF- compared with CP pts. Conclusion: Shear wave elastography appears to be an extremely valuable tool to diagnose muscle weaknesses in patients with chronic heart failure.

Biography:

Multiple GWAS and meta-analysis studies have implicated the role of 9p21 chromosomal region to be associated with coronary artery disease (CAD). Till date no data pertaining to rs1333049 G>C variant of non-coding RNA in the INK4 locus (ANRIL) and CAD risk has been documented in the North Indian population. The high propensity of Indians to develop CAD demands studies on genetic markers linked with increased risk in this population group

Abstract:

Biography:

Kucherenko Kirill Nikolayevich is a student of the medical faculty of the medical university "Reaviz" in the city of Samara, directs the work of the scientific society of students, performs scientific research in the clinical centers of this medical university. The field of scientific interests is related to cardiology. The results of scientific research are presented at various scientific conferences (XXIII Congress of the I.P. Pavlov Physiological Society, Voronezh, 2017; XXIII All-Russian Conference of Young Scientists with International Participation, St. Petersburg, 2017 and others)

Abstract:

According to clinical and experimental studies (Rosenman, 1975, Friedman, Bokenberger et al., 2014, Steca et al., 2016) type A behavior pattern (TABP) is a risk factor for the development of coronary heart disease, atherosclerosis and other cardiovascular pathologies.  The data available to date on TABP are based on clinical observations of patients in the older age group (30-60 years).  In this study, the daily monitoring of cardiac and hemodynamic parameters was conducted, the features of the mechanisms of blood circulation regulation and its adaptive potential in students of the medical university aged 20-22 (n=144) with different types of behavior were studied.  It was found that during the training sessions and during night sleep in students with TABP, the mean values ​​of blood pressure, heart rate were maintained at a higher level compared to students with behavior of the type AB and B. Performing an orthostatic test and Martine test in students with TABP led to a pronounced activation of sympathetic adrenal mechanisms and the formation of less adaptive reactions of the cardiovascular system.  In some cases, the pathological type of response to functional loads was determined.  Students with TABP had a lower cortisol level in the morning.  This fact may indicate a possible violation of the circadian rhythm of the development of this adaptive hormone.  It is concluded that students with severe TABP are at risk for developing cardiovascular diseases and need an effective system for the prevention of this pathology

Biography:

Rebecca Perez de Amorim is a student on her 4^th year of medical school at the University of the State of Pará in Brazil. She assists Doctor Moacyr Magno Palmeira in his researches. Palmeira has a Ph.D. in Biological Sciences from the University of the State of Pará, a Master’s of Cardiology from the Federal University of São Paulo, is a Cardiology Specialist from the Brazilian Society of Cardiology, and Doctor in the Urgency and Emergency department at Gaspar Vianna Public State Hospital Foundation

Abstract:

Acute aortic dissection (AAD) is a lethal and prevalent cardiovascular emergency. Atrioventricular conductivity disorders caused by coronary artery dissection involving AAD are rare. When it happens, both coronary arteries can be affected and acute myocardial infarction (AMI) is the most frequent clinical sign. Many deceased patients do not have the diagnosis confirmed until autopsy, and 85% receive the wrong therapy as a result of misdiagnosis. A 49-year-old male patient presenting prolonged, intense, sharp precordial pain radiating to his back, along with cold sweats, nausea and vomiting, was admitted to the cardiac emergency service. Thoracic examination revealed normal bilateral breath sounds and a respiratory rate of 24 incursions/min (SpO2 97%). Cardiac auscultation revealed a regular, bradycardiac rhythm. There was a visible high-intensity pulsation in the suprasternal notch, a diastolic murmur audible on the aortic focus, and a fourth heart sound on auscultation. After stabilization, a hemodynamic evaluation was run for urgent catheterization that showed an aortic dissecting aneurysm and a right coronary false lumen area. The patient was diagnosed with Stanford type A AAD, concomitant complete atrioventricular block, and impairment of the right coronary artery, progressing to acute coronary syndrome and spontaneous rupture of the aortic aneurysm. The patient was transferred to urgent surgical treatment and died during surgery. Physical examination is essential to disregard AAD as the main cause of AMI. The consequences of a misdiagnosis can be fatal if thrombolytic or anticoagulant therapy is chosen as the initial treatment; therefore, surgery is the best treatment for aortic dissection

Biography:

Rebecca Perez de Amorim is a student on her 4^th year of medical school at the University of the State of Pará in Brazil. She assists Doctor Moacyr Magno Palmeira in his researches. Palmeira has a Ph.D. in Biological Sciences from the University of the State of Pará, a Master’s of Cardiology from the Federal University of São Paulo, is a Cardiology Specialist from the Brazilian Society of Cardiology, and Doctor in the Urgency and Emergency department at Gaspar Vianna Public State Hospital Foundation

Abstract:

Cytomegalovirus (CMV) infection commonly leads to default of symptoms in immunocompetent individuals. Complications are unusual. In the presented research, a case of myocarditis and cardiac insufficiency due to primary CMV infection was reported. The ELISA method was used to confirm the presence of the vírus. A 41-year-old man without previous comorbidities presenting dyspnea, fever and edema was admitted to the cardiac emergency department. His fever and dry cough worsened to progressive respiratory disorders, lower limb edema and orthophonia 30 days before hospitalization. The electrocardiogram revealed sinus tachycardia, right bundle branch block and left atrial and ventricular overload, along with diffuse and non-specific ventricular repolarization disorders. A transthoracic echocardiogram revealed 35% ejection fraction (EF) of the left ventricle (LV) and an increase in the left cavity (70 mm LV). Serological tests were performed for HIV-1 and HIV-2, hepatitis B and C, and Chagas disease, all with negative results. For CMV, ELISA showed positive results for IgM (1.54 UI/mL) and IgG (2.5 UI/mL). The patient was diagnosed with heart failure due to CMV myocarditis. He was treated with ganciclovir for 10 days and received supportive medication, he was discharged in functional class I (New York Heart Association) after 14 days of hospitalization. One month after discharge, a routine echocardiography showed EF LV = 75% and almost normal values for the diameter of the left chambers. This case reaffirms the possibility of cardiac involvement in CMV infection and emphasizes the importance of viral etiologies as differential diagnoses for acute myocarditis

Biography:

Abstract:

BACKGROUND:  Adverse cardiovascular habits often form early in life and many young people are not educated about health habits. Finding ways to engage adolescents and young adults with health messages is one strategy to improving cardiovascular health. In order to best design appropriate health messages, we employed surveys to evaluate health status of young people

METHODS:  A cohort of 57 adolescents and young adults between ages 13-25 were recruited from U.S. middle schools, high schools, and colleges. We collected baseline in order to assess the feasibility of delivering weekly health questions and tips via automated text messages.  Surveys were administered assessing diet quality, physical activity, stress levels, hours of sleep, and tobacco use using a scaled response (graded from 1 to 5, or from none to always). This study has been approved by the UCLA Institutional Review Board.

RESULTS: Mean age of participants was 19.7 + 1.9 years (67.8% female).  Only 9% of respondents felt “very knowledgeable” about heart disease or cardiovascular risk factors.  62% admitted they did not know how to prevent heart disease.  Most participants do not smoke, most eat high quality diets and most sleep at least 7 hours nightly.  Most participants feel that stress is their greatest risk factor for heart disease.  When asked “In the last 3 months how often were you stressed or had trouble relaxing?” 95% responded “half of the time.” 

DISCUSSION:  Among U.S. adolescents and young adults knowledge about heart disease and cardiovascular risk factors is low.  Fortunately tobacco use is declining and diets are improving among adolescents and young adults in the U.S.. Unfortunately stress is highly prevalent and many young people feel unprepared to address this risk factor and this may adversely affect future cardiovascular health